Department of Anesthesiology, Stony Brook University, HSC Level 4, Rm 060 Stony Brook, NY 11794-8480, USA. Lotus Clinical Research, LLC, Pasadena, CA 91105, USA. Premier Research, Austin, TX 78705, USA. Magidom Discovery, LLC, Lindenhurst, IL 60046 USA; Brown University School of Medicine, Providence, RI 02912 USA. Hospira, a Pfizer company, Lake Forest, IL 60045, USA. Javelin Pharmaceuticals, Inc, Cambridge, MA, USA (now Hospira, a Pfizer company, Lake Forest, IL 60045, USA); Department of Anesthesiology, Tufts Medical Center, Boston, MA 02111, USA. Electronic address: daniel.carr@tufts.edu.